Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.
Diabetologia, 2012, Vol 55, Issue 12, p. 3245-51
Aged; Blood Glucose; Fasting; Female; Finland; Follow-Up Studies; Genetic Variation; Genotype; Humans; Insulin; Insulin Resistance; Islets of Langerhans; Male; Middle Aged; Predictive Value of Tests; Proprotein Convertase 2; Prospective Studies; Risk Assessment; Sweden