1 Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet
Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.
Diabetologia, 2012, Vol 55, Issue 12, p. 3245-51
Aged; Blood Glucose; Fasting; Female; Finland; Follow-Up Studies; Genetic Variation; Genotype; Humans; Insulin; Insulin Resistance; Islets of Langerhans; Male; Middle Aged; Predictive Value of Tests; Proprotein Convertase 2; Prospective Studies; Risk Assessment; Sweden