Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.
Diabetologia, 2012, Vol 55, Issue 12, p. 3341-9
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't