The mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like cocaine. The muscarinic M(4) acetylcholine receptor subtype is centrally involved in the regulation of dopamine release in striatal areas. Consequently, striatal M(4) receptors could be a novel target for modulating psychostimulant effects of cocaine.
Psychopharmacology, 2012, Vol 224, Issue 2, p. 277-87
Journal Article; Research Support, Non-U.S. Gov't; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Mice; Mice, Knockout; Motor Activity; Pyridines; Receptor, Muscarinic M4; Reinforcement (Psychology); Self Administration; Thiophenes