Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4% gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.
Journal of Biomedical Materials Research, 1992, Vol 26, Issue 6, p. 791-800
Absorption; Animals; Biocompatible Materials; Bone and Bones; Collagen; Drug Combinations; Fibrin; Gentamicins; Hemostatics; Inflammation; Male; Materials Testing; Osteogenesis; Palmitates; Polyesters; Rats; Rats, Inbred Strains; Waxes