Standard treatment of critically ill patients undergoing mechanical ventilation is continuous sedation. This standard treatment to all patients has been greatly challenged over the last decade. At the general intensive care department at Odense University hospital the standard treatment has been no sedation. The general impression has been that this reduces time in mechanical ventilation and reduces complications such as acute renal failure. It has not been the impression that this treatment increased the risk of long term psychological problems compared to standard treatment with sedation. The "no-sedation" method has however never been described in the literature or tested in a prospective randomized trial. Hypothesis: The main hypothesis was that a no sedation strategy reduces the time patients receive mechanical ventilation, decrease intensive care and total length of hospital stay. Secondary endpoints were: a no sedation strategy would reduce secondary organ failure such as kidney injury and would not increase the risk of post-traumatic stress disorder after hospital discharge.
Danish Medical Bulletin (online), 2012, Vol 59, Issue 5