Nielsen, Mette Lundgren2; Pareek, Manan2; Henriksen, Jan Erik2
1 Endocrinology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU2 Endocrinology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
Statin treatment can cause muscular side effects. It has been suggested that the mechanism is reduced synthesis of coenzyme Q10 (coQ10) and a subsequent dysfunction of the respiratory chain. A literature review resulted in insufficient evidence supporting this theory. It is uncertain whether intramuscular levels of coQ10 and mitochondrial function are affected by statin therapy and whether the symptoms of myopathy can be alleviated with coQ10 supplementation. Nevertheless, due to a favourable safety profile, coQ10 can be tested in patients whose muscular symptoms cannot be managed otherwise.
Ugeskrift for Laeger, 2011, Vol 173, Issue 46, p. 2943-8