1 Faculty of Science, SDU2 Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU3 NAC, Institut for Fysik og Kemi, Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU4 Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
The influence of acyclic RNA derivatives, UNA (unlocked nucleic acid) monomers, on i-DNA thermodynamic stability has been investigated. The 22 nt human telomeric fragment was chosen as the model sequence for stability studies. UNA monomers modulate i-motif stability in a position-depending manner. The largest destabilization is observed for position C14, while UNA placed in position A12 causes significant increase of i-DNA thermodynamic stability. CD curves of UNA-modified variants imply no structural changes relative to the native i-motif.
Bioorganic and Medicinal Chemistry Letters, 2011, Vol 21, Issue 2