A Finite-Difference Time-Domain Approach to the Modeling of Flow Cytometry Configurations
This chapter has two main objectives. First, to review a number of examples illustrating the application of the FDTD approach to the modeling of some typical light scattering configurations that could be associated with flow cytometry. Second, to provide a thorough discussion of these new developments in advanced cytometry research by pointing out potential new research directions. A brief description of the FDTD method focusing on the features associated with its application to modeling of light scattering and OPCM cell imaging experiments is provided. The examples include light scattering from OPCM imaging of single biological cells in conditions of controlled refractive index matching (RIM) and labeling by diffused and clustered gold NPs. The chapter concludes with a discussion and suggestions for future research.
Advanced Optical Cytometry: Methods and Disease Diagnoses, 2011, p. 35-62