Jackson, Petra2; Vogel, Ulla1; Wallin, Håkan2; Hougaard, Karin Sørig2
1 The Department of Science, Systems and Models, Roskilde University2 unknown
Effects on Sexual Development and Neurofunction
Maternal pulmonary exposure to ultrafine particles during pregnancy may affect the health of the child. Developmental toxicity of carbon black (Printex 90) nanoparticles was evaluated in a mouse model. Time-mated mice were intratracheally instilled with Printex 90 dispersed in Millipore water on gestation days (GD) 7, 10, 15 and 18, with total doses of 11, 54 and 268 mu g Printex 90/animal. The female offspring prenatally exposed to 268 mu g Printex 90/animal displayed altered habituation pattern during the Open field test.
Basic and Clinical Pharmacology and Toxicology, 2011, Vol 109, Issue 6, p. 434-437