Knowledge of regulation relations is widely applied by biomedical researchers in for example experiment design on regulatory pathways and in systems biology. Such knowledge has typically been represented very roughly as simple graphs or very expressively in simulations of pathways. In the work presented here, we analyze 6 frequently used verbs denoting the regulation relations regulates, positively regulates and negatively regulates through corpus analysis, and propose a formal representation of the acquired knowledge as domain speci¯c semantic frames. The acquired knowledge patterns can thus be used to identify and reason over knowledge represented in texts from the biomedical domain.
Main Research Area:
4th International Symposium on Semantic Mining in Biomedicine, 2010