1 The Department of Communication, Business and Information Technologies, Roskilde University2 The Department of Culture and Identity, Roskilde University3 Programming, Logic and Intelligent Systems, Department of People and Technology, Roskilde University4 Videnskabsstudier, Department of Communication and Arts, Roskilde University5 Department of People and Technology, Roskilde University
Knowledge on regulatory relations, in for example regulatory pathways in biology, is used widely in experiment design by biomedical researchers and in systems biology. The knowledge has typically either been represented through simple graphs or through very expressive differential equation simulations of smaller parts of a pathway. In this work we suggest a knowledge representation of the most basic relations in regulatory processes regulates, positively regulates and negatively regulates in logics based on a semantic analysis. We discuss the usage of these relations in biology and in articial intelligence for hypothesis development in drug discovery.
Lecture Notes in Computer Science: 1st International Conference on Information Technology in Bio- and Medical Informatics, 2010, p. 186-200