A cancer patient receiving long-term oral sustained-release morphine treatment and periodically presenting with unusually high plasma M3G/M6G ratios is described. We found the patient's formation of M6G more unstable and perhaps delayed compared to the formation of M3G. There is no apparent explanation for this phenomenon and the high M3G/M6G ratios had no implications for the patient's pain experience or side effects from the morphine treatment.
Journal of Pain and Symptom Management, 2002, Vol 23, Issue 2, p. 161-4
Analgesics, Opioid; Central Nervous System Stimulants; Humans; Male; Middle Aged; Morphine; Morphine Derivatives; Pain; Prostatic Neoplasms; Time Factors