This paper examines the factors that drive the success of multinational corporations (MNCs) in their pursuit of regional strategies. We develop a comprehensive regional success factor model to investigate the effects of regional management autonomy and regional product/service adaption on the regional success of MNCs. Using structural equation modelling, we also analyze the interaction effects of regional orientation and inter-regional distance. We evaluate our model by means of both primary and secondary data for Fortune Gloval 500 firms. Our findings show that appropriate degrees of regional management autonomy and regional product/service adaption are higly contingent upon contextual influences on MNCs.