1 Department of Experimental Clinical Oncology, Faculty of Health Sciences, Aarhus University, Aarhus University2 Department of Physics and Astronomy, Faculty of Science, Aarhus University, Aarhus University3 Nuclear Chemistry, University of Mainz4 Department of Pathology, University of Mainz5 Department of Nuclear and Theoretical Physics University of Pavia, Pavia6 National Institute of Nuclear Physics (INFN) Pavia Section, Pavia7 Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universität München, D-85748 Garching8 Joint Research Centre (JRC) of the European Commission, NL-1755 ZG Petten9 Department of Physics and Astronomy, Science and Technology, Aarhus University10 Molecular Medicine, Health & Environment Department, AIT Austrian Institute of Technology GmbH11 National Physical Laboratory, Teddington TW11 0LW, Middlesex12 Department of Hepatobiliary, Pancreatic and Transplantation Surgery, University of Mainz, D-55099 Mainz13 Department of Physics and Astronomy, Science and Technology, Aarhus University
The thermal column of the TRIGA reactor in Mainz is being used very effectively for medical and biological applications. The BNCT (boron neutron capture therapy) project at the University of Mainz is focussed on the treatment of liver tumours, similar to the work performed at Pavia (Italy) a few years ago, where patients with liver metastases were treated successfully by combining BNCT with auto-transplantation of the organ. Here, in Mainz, a preclinical trial has been started on patients suffering from liver metastases of colorectal carcinoma. In vitro experiments and the first animal tests have also been initiated to investigate radiobiological effects of radiation generated during BNCT. For both experiments and treatment, a reliable dosimetry system is necessary. From work elsewhere, the use of alanine detectors appear to be an appropriate dosimetry technique.