Hypophosphatemic rickets (HR) are diseases characterized by deficient mineralization of bone due to abnormal renal wasting of phosphate. In patients with HR, cranial structures of cartilaginous as well as of membranous origin are affected. The AIM of the present study was to characterize the size and the morphology of osseous structures (the anterior cranial base, the nasal bone and the frontal sinus) in the fronto-nasal field, in adults with HR compared to healthy controls. METHODS. Standardized profile radiographs of 36 patients with HR (24 females, 12 males), aged 18 – 74 yrs, and 49 controls (26 females, 23 males), aged 18 – 79 yrs. Cephalometric analysis included: the sella-nasion length, the height and the width of the frontal sinus, the length and the width of the nasal bone. The comparison between HR-patients and controls were performed by linear regression analyses adjusting for age and gender. RESULTS. The width of the nasal bone proximally, and the ratio between the proximal width and the axial length of the nasal bone was significantly increased in HR-patients in comparison with controls (p<0.05). The nasal bone of HR-patients was less slender and looked shorter than in controls. Neither the height nor the width of the frontal sinus was significantly affected (p-values: 0.41 – 0.86). Sella-nasion length was not significantly affected (p = 0.202) CONCLUSION. In a group of HR-patients, the morphology of the nasal bone was abnormal in comparison with healthy controls. In contrast, other osseous structures of the fronto-nasal field were unaffected (the anterior cranial base, the frontal sinus).