The present study belongs to an extensive project in which we investigate knowledge issues appearing in academic research article, academic visual essay and academic video essay. The data of our analysis which comprises prototype research articles in 7 scientific disciplines is collected from the homepage of Article of the Future project: http://www.articleofthefuture.com/. The Article of the Future project is an ongoing initiative aiming to revolutionize the traditional format of the research article. In order to deal with and reflect upon the implications related to knowledge dissemination of the new multi-resources flows proposed in the prototype articles, we adopt a multimodal approach in our analysis. We address the semiotic modes’ interaction and combination in order to identify the roles of the semiotic interplay in creating and multiplying meaning at various levels of the generic organization. The exploration of these prototype articles is also facilitated by applying theoretical approaches related to information design and actionable knowledge. We focus on how the decisional power is enhanced by the multiple reading paths and interactional possibilities offered by the temporal sequentiality and spatial proximity of the multimodal three-pane article view. This study aims to extend the focus on ‘asymmetric’ communication between experts and lay-people, and addresses asymmetries that can appear between experts due to the new requirements for disseminating academic knowledge. The findings of this research work can contribute to a better understanding of the strategies required today and in the future for disseminating academic knowledge across several semiotic modes and media in research genres.