Background: There are indications that balance of magnesium (Mg) ions may regulate mood. Magnesium deficiency is also linked with altered glucose metabolism and an inflammatory response in the gut. In addition, mood disorders have been linked to a dysfunctional metabolism. Aim: In this study we investigated the involvement of Mg in regulating depression-and anxiety-like behaviour and metabolism, by using mice that have been deprived of dietary Mg and studying several behavioral and metabolic markers. Methods: We examined the behavioral effects of Mg deficiency (deprival of dietary Mg for 6 weeks) in mice through depression-and anxiety phenotyping experiments, namely the forced swim test and light-dark box respectively. We determined the behavioural effects 30 minutes after treatment with imipramine (20 mg/kg), diazepam (2 mg/kg) and ketamine (3 mg/kg). The glucose tolerance test was used to assess metabolic function in Mg deficient mice. Results: We found that, compared to control (n=10), mice receiving Mg deficient diet (n=10) (10 % RDA), were more immobile in the forced swim test.
Acta Neuropsychiatrica, 2012, Vol 24
diazepam imipramine ketamine marker glucose magnesium ion anxiety mouse college psychopharmacology magnesium deficiency glucose tolerance test metabolism forced swim test nutritional deficiency phenotype mood mood disorder intestine inflammation glucose metabolism diseases supplementation