; ; ; ; ; ; ; ; ; ; ; ;
1 Department of Policy Analysis, National Environmental Research Institute, Aarhus University, Aarhus University 2 IME 3 Department of Environmental Science - Environmental chemistry & toxicology, Department of Environmental Science, Science and Technology, Aarhus University 4 P&G 5 Sasol 6 Cognis 7 KAO 8 Shell 9 PFA 10 Department of Environmental Science - Environmental chemistry & toxicology, Department of Environmental Science, Science and Technology, Aarhus University
Daphnia magna reproduction tests were performed with C10, C12, C14 and C15 alcohols to establish a structure-activity relationship of chronic effects of long-chain alcohols. The data generation involved substantial methodological efforts due to the exceptionally rapid biodegradability of the test substances and the need to test as close as possible to their water solubility limits. Test concentrations were determined by GC-MS before and after test solution renewal. Whereas apparent toxicity based on survival and reproduction increased with increasing C-chain lengths up to C14, observations of toxicity to C15 alcohol were not in line with lower chain lengths due to the lack of toxicity below the level of water solubility. When omitting C15, the slope of most (Q)SARs approach -1, being consistent with the expectation of a non-polar narcotic mode of action. Further testing at higher chain lengths is not sensible due to progressively lower solubility, at remaining biodegradability. Effects on mortality and reproduction are not expected below the level of water solubility. © 2008 Elsevier Inc. All rights reserved.
Ecotoxicology and Environmental Safety, 2009, Vol 72, Issue 4, p. 996-1005
Main Research Area: