Pathogen-recognizing Toll-like receptors 2 (TLR2) and TLR4 are known to recognize a number of pathogens, including E.Coli, S. Pneumoniae and N. Meningitidis. We have studied whether a number of HIV therapeutics affect immediate proinflammatory cytokine responses in cell cultures. Preliminary results suggest an opposing effect of the drugs Tenofovir and Retrovir (AZT) on TLR-mediated proinflammatory cytokine production. We present data on the mechanisms behind the drug-mediated remodeling of innate immune activation and how the drugs effect early host-pathogen interactions.
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The 25th Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy, 2008