1 Interdisciplinary Nanoscience Center, Science and Technology, Aarhus University2 Department of Chemistry, Science and Technology, Aarhus University3 Interdisciplinary Nanoscience Center - INANO-Kemi, iNANO-huset, Interdisciplinary Nanoscience Center, Science and Technology, Aarhus University4 Interdisciplinary Nanoscience Center - INANO-Kemi, iNANO-huset, Interdisciplinary Nanoscience Center, Science and Technology, Aarhus University
Starting from the development of the first electrochemical biosensor for glucose, as far as in 1962, the electrochemical biosensor research area underwent a dramatic evolution both in scientific and commercial directions. At present, electrochemical biosensors are widely used in medical practice, by offering extremely sensitive and accurate yet simple, rapid, and inexpensive biosensing platforms (1). In this talk, I will discuss the developed at iNANO reagentless enzymatic biosensors, in which the enzyme is directly electronically coupled to the electrode (1-3), and advanced genosensor platforms for nanomedicine, based on DNA and RNA architectures (1, 4, 5), in which binding of the analyte results in the electrochemically translatable conformational nanoswitching of nucleic acids, with a special emphasis on electronic molecular beacon systems for genetic and small-molecule electroanalysis. Future perspectives of the biosensor research and such biotechnological applications as enzyme electrodes for sustainable energy production (6) will be discussed.