1 Department of Dentistry and Oral Health - Department of Dental Pathology, Operative Dentistry and Endodontics, Department of Dentistry and Oral Health, Health, Aarhus University2 Department of Dentistry and Oral Health - Department of Dental Pathology, Operative Dentistry and Endodontics, Department of Dentistry and Oral Health, Health, Aarhus University
a new direction in regeneration of dental hard tissue
Original Mineral Trioxide Aggregate (MTA) has been recommended for various uses in endodontics. MTA is a calcia, silica, alumina containing hydraulic cement with long setting time, calcium hydroxide release, and high pH. It possesses antibacterial and sealing properties. Interestingly, recent studies describe hydroxyapatite crystals form over MTA when it comes in contact with simulated physiological tissue fluid. On the basis of available evidence it appears that MTA efficiently develop superior marginal adaptation in humid environments. Observations suggest MTA is suitable material for pulp capping. and that it is a highly biocompatible material. MTA has as drawbacks high costs, potential discoloration, and 3h setting time (1). Novel technology developed at Aarhus University is basis for novel nano-hybrid MTA (called iMTA) with fast setting time and fluoride release. iMTA contain a slightly modified calcia-silica-alumina-sulphate composition with soluble fluorides, radiocontrast material, and nanosilicate. iMTA thereby demonstrate a remarkably high compressive strength in comparison to several commonly used dental cements. Reduction of iMTA setting time to 2-10 min with either flowable or condensable consistency, makes it a relevant option for new practical applications including e.g. lining, temporary restorations, and band cementation. The limited fluoride release in combination with high calcium hydroxide release from iMTA is designed for pulp-dentin regeneration and caries prevention, further investigations are needed in order to study the properties and activity of iMTA. References M. Parirokh, M Torabinejad. Mineral trioxide aggregate: a comprehensive literature review (III): Clinical applications, drawbacks, and mechanism of action. J Endod. 2010 Mar;36(3):400-13.