As a consequence of a new law regulating the Danish dental care systems, and with inspiration from the TAKO-centre, Oslo and the Mun-H-Center, Gothenburg - two Danish Resource Centres for oral health in rare conditions were established in 2002. The intention of the law was to centra-lise systematic collection of information and knowledge of dental and oral health problems in rare conditions in order to improve the service and the quality of dental treatment for groups of patients with special needs. Aim: To report the results of setting up ressource centres for oral health in rare conditions, in Denmark. Material: 1290 patients were referred during 2002-2009. A: 553 patients had congenital, rare dental anomalies and B: 737 patients had rare medical conditions or handicaps affecting the oral and dental tissues. This group included 70-80 different medical diagnoses. The median age was 12.6 years (0.5-73) and the male/female ratio was equal (1.06) Results: A: Oligodontia (N=154 ) and Amelogenesis Imperfecta (N=146 ) were the most frequently diagnosed dental anomalies. B: Osteogenesis Imperfecta (N=88), Ectodermal Dysplasia (N=81), Ehlers Danlos Syndrome (61) and Marfan Syndrome (N=44) were the largest groups of rare disorders.Conclusions: Centralisation of diagnostic procedu-res, specialised treatment and follow-up evaluation create a valuable basis for increased knowledge of rare conditions. A knowledge that health professionals, politicians, other caregivers and patients may benefit from.