Atherosclerosis is the leading cause of death and severe disability. Wall Shear Stress (WSS), the stress exerted on vessel walls by the flowing blood is a key factor in the development of atherosclerosis. Computational Fluid Dynamics (CFD) is widely used for WSS estimations. Most CFD simulations are based on static models to ease computational burden leading to inaccurate estimations. The aim of this work was to estimate the effect of vessel wall deformations (expansion and bending) on WSS levels.