1 Dynamical systems, Department of Mathematics, Technical University of Denmark2 Department of Mathematics, Technical University of Denmark3 Heidelberg University4 Max Planck Institute5 Fritz-Haber Institute of the Max-Planck-Society
We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
Biophysical Journal, 2006, Vol 90, Issue 4, p. 1147-1155