1 Department of Informatics and Mathematical Modeling, Technical University of Denmark2 Operations Research, Department of Informatics and Mathematical Modeling, Technical University of Denmark3 Department of Management Engineering, Technical University of Denmark
We give a review of pharmaceutical R&D and mathematical simulation and optimization methods used to support decision making within the pharmaceutical development process. The complex nature of drug development is pointed out through a description of the various phases of the pharmaceutical development process. A part of the paper is dedicated to the use of simulation techniques to support clinical trials. The paper ends with a section describing portfolio modelling methods in the context of the pharmaceutical industry.
Pharmaceutical R&D; Drug Discovery and Development; Modelling and simulation; Clinical Trial Simulation Portfolio optimization