Kjærstad, Mia Birkhøj2; Andersen, Helle Raun3; Taxvig, Camilla2; Hass, Ulla2; Petersen, Marta Axelstad2; Metzdorff, Stine Broeng2; Vinggaard, Anne4
1 Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark2 National Food Institute, Technical University of Denmark3 University of Southern Denmark4 Copenhagen Center for Health Technology, Center, Technical University of Denmark
Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.