1 Image Analysis and Computer Graphics, Department of Informatics and Mathematical Modeling, Technical University of Denmark2 Department of Informatics and Mathematical Modeling, Technical University of Denmark3 unknown
This report describes and evaluates the steps needed to perform modern model-based interpretation of the corpus callosum in MRI. The process is discussed from the initial landmark-free contours to full-fledged statistical models based on the Active Appearance Models framework. Topics treated include landmark placement, background modelling and multi-resolution analysis. Preliminary quantitative and qualitative validation in a cross-sectional study show that fully automated analysis and segmentation of the corpus callosum are feasible.
brain MRI; segmentation; MDL; corpus callosum; active appearance models