Christoffersen, Gert Rene Juul4; Skibsted, Leif H3
1 AKI 1, Department of Molecular Biology, Faculty of Science, Københavns Universitet2 Sensory and Consumer Science, Department of Food Science, Faculty of Science, Københavns Universitet3 Univ. of Copenhagen4 Sensory and Consumer Science, Department of Food Science, Faculty of Science, Københavns Universitet
1. Substitution by different anions for chloride in physiological salt solutions leads to binding between Ca2+ and the anion. Experiments designed to test effects of Cl- therefore often show mixed effects of changes in Cl- and Ca2+ activity. 2. This mixed effect is demonstrated in neurons of the snail, Helix pomatia: current-voltage characteristics and membrane potential are described during reduction of extracellular Cl- using different anions as substitutes. Methylsulphate is concluded to be the best substitute in this preparation. 3. The association constants for the binding of Ca2+ to a number of anions is given.
Comparative Biochemistry and Physiology - Part A: Comparative Physiology, 1975, Vol 52, Issue 2, p. 317-322