Gjetting, Torben1; Arildsen, Nicolai Skovbjerg2; Christensen, Camilla Laulund1; Poulsen, Thomas Tuxen1; Roth, Jack A2; Handlos, Vagn Neerup2; Poulsen, Hans Skovgaard1
1 Onkologisk Klinik, Finsencentret, Rigshospitalet, The Capital Region of Denmark2 unknown
DOTAP/cholesterol-based lipoplexes are successfully used for delivery of plasmid DNA in vivo especially to the lungs, although low systemic stability and circulation have been reported. To achieve the aim of discovering the best method for systemic delivery of DNA to disseminated tumors we evaluated the potential of formulating DOTAP/cholesterol lipoplexes with a polyethylene glycol (PEG)-modified lipid, giving the benefit of the shielding and stabilizing properties of PEG in the bloodstream.
International Journal of Nanomedicine, 2010, Vol 5, p. 371-83