Abreu, L.M.5; Phipps, Richard Kerry2; Pfenning, L.H.5; Gotfredsen, Charlotte Held4; Takahashi, J.A.5; Larsen, Thomas Ostenfeld6
1 Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark2 Department of Systems Biology, Technical University of Denmark3 Organic Chemistry, Department of Chemistry, Technical University of Denmark4 Department of Chemistry, Technical University of Denmark5 unknown6 Natural Product Discovery, Department of Biotechnology and Biomedicine, Technical University of Denmark
Cytosporones O, P and Q, together with the known compounds cytosporones B, C, D, E and dothiorelones A, 13, C. and H were isolated from the ascomycete fungus Cytospora sp. during a chemotaxonomic study Of fungal endophytes belonging to the related genera Cytospora and Phomopsis from Brazil. The structures were determined by NMR spectroscopy and mass spectrometry. With exception of cytosporones D, E, Q and dothiorelone B, all compounds were consistently detected in the metabolite profiles of eight Cytospora isolates investigated; and were also produced by a distinct chemotype of Phomopsis.
Tetrahedron Letters, 2010, Vol 51, Issue 13, p. 1803-1805