1 Helin Group, BRIC Research Groups, BRIC, Københavns Universitet2 BRIC, BRIC, Københavns Universitet3 BRIC Administration, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet4 Helin Group, BRIC Research Groups, BRIC, Københavns Universitet5 BRIC Administration, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet
Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant patterns of gene expression. In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer. In this review, we focus on a subclass of epigenetic regulators, namely histone methyltransferases (HMTs). Several HMTs have been linked to different types of cancer; however, in most cases we only have limited knowledge regarding the molecular mechanisms by which the HMTs contribute to disease development. We summarize the current knowledge regarding some of the best-validated examples of HMTs contributing to tumorigenesis and discuss their potential mechanisms of action.
Seminars in Cell and Developmental Biology, 2009, Vol 21, Issue 2, p. 209-20