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Solvent-free enzymatic synthesis of 1,3-diconjugated Linoleoyl Glycerol Optimized by Response Surface Methodology

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Authors:
  • Guo, Zheng ;
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    Department of Engineering - Lipid Biotechnology and Engineering, Department of Engineering, Science and Technology, Aarhus University
  • Sun, Yan
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    Tianjin University
DOI:
10.1021/bp034212m
Abstract:
An operation mode with N2 bubbling under vacuum was employed for the solventfree synthesis of 1,3-diconjugated linoleoyl glycerol (1,3-dCLG) from conjugated linoleic acid (CLA) catalyzed by Novozym 435. The response surface methodology (RSM) was adopted for the optimization of the reaction conditions with five major factors (incubation time, temperature, enzyme load, substrate mole ratio, and system vacuum) and three responses (CLA conversion, 1,3-dCLG yield, and acyl migration). Two sets of optimal conditions were recommended. Validation of the RSM model was verified by the good agreement between the experimental and the predicted values of 1,3- dCLG yield. Under the optimal conditions, the yield of 1,3-dCLG up to 93% was obtained. The reaction was scaled up to a production level of 100 g of 1,3-dCLG at a yield of 90.7%, indicating a promising feature of the technology in industrial applications.
Type:
Journal article
Language:
English
Published in:
Biotechnology Progress, 2004, Vol 20, Issue 2, p. 619-625
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2004
Scientific Level:
Scientific
ID:
1085144

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