Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

D.E. Postnov; R.N. Koreshkov; N.A. Brazhe; A.R. Brazhe; Olga Sosnovtseva

doi:10.1007/s10867-009-9156-x

Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

Authors:

Postnov, D.E. ;
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Koreshkov, R.N. ;
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Brazhe, N.A. ;
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Brazhe, A.R. ;
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Sosnovtseva, Olga
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Department of Physics, Technical University of Denmark

DOI:

10.1007/s10867-009-9156-x

Abstract:

We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

Type:

Journal article

Language:

English

Published in:

Journal of Biological Physics, 2009, Vol 35, Issue 4, p. 425-445

Keywords:

Astrocyte; Tripartite synapse; Modeling; Neuron; Calcium waves

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2009

Scientific Level:

Scientific

ID:

1068500

Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

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