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Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

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Authors:
  • Postnov, D.E. ;
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    unknown
  • Koreshkov, R.N. ;
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    unknown
  • Brazhe, N.A. ;
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    unknown
  • Brazhe, A.R. ;
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    unknown
  • Sosnovtseva, Olga
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    Department of Physics, Technical University of Denmark
DOI:
10.1007/s10867-009-9156-x
Abstract:
We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.
Type:
Journal article
Language:
English
Published in:
Journal of Biological Physics, 2009, Vol 35, Issue 4, p. 425-445
Keywords:
Astrocyte; Tripartite synapse; Modeling; Neuron; Calcium waves
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2009
Scientific Level:
Scientific
ID:
1068500

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